August 2006
Trends and Tools in Bioinformatics and Computational Biology
Wilfred W. Li, University of California, San Diego (UCSD), San Diego Supercomputer Center (SDSC)
Nathan Baker, Washington University in Saint Louis
Kim Baldridge, UCSD, SDSC
J. Andrew McCammon, UCSD
Mark H. Ellisman, UCSD, Center for Research In Biological Systems (CRBS)
Amarnath Gupta, UCSD, SDSC
Michael Holst, UCSD
Andrew D. McCulloch, UCSD
Anushka Michailova, UCSD
Phil Papadopoulos, UCSD, SDSC
Art Olson, The Scripps Research Institute (TSRI)
Michel Sanner, TSRI
Peter W. Arzberger, California Institute for Telecommunications and Information Technology (Calit2), CRBS, UCSD

4.3. Future directions

In developing collaborations and ultimately a user base to conduct research, having a persistent infrastructure is required. By this we mean access to tools and software for researchers to experiment with. The National Centers for Research Resources provide that type of infrastructure for the community. In the case of NBCR, access to the tools and services discussed in this article can be found at the NBCR 9 website.
While the experiences and developments discussed above have been informed by our local activities, the concepts of cyberinfrastructure are not bound by national borders. Examples of large scale projects and smaller team projects have been commented on in prior CTWatch issues (e.g., February 2006). Furthermore, it is essential that we actively participate in the international arena, both to ensure the various CI efforts can interoperate (e.g., when we want to use unique resources in other countries) and to reduce reproduction of tools that already exist.

Another exciting development that will link biomedical research with the environment across various scales is the newly funded CAMERA project. CAMERA will provide a community resource that links genetic information from a metagenomics effort, the Global Ocean Survey, with environmental factors such location, temperature and chemistry of the sampled environment.

The critical role played by NBCR to bridge the multiscale modeling research community and cyberinfrastructure is an important one, and will require collaborative efforts from other projects to expedite the translational/medical potential of multiscale biomedical and cyberinfrastructure research.

The authors are all members of the National Biomedical Computation Resource, which is supported by the NIH National Centers for Research Resources award P41-RR08605. Major support for APBS is provided by NIH grant GM069702 to NAB.
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Reference this article
Li, W. W., Baker, N., Baldridge, K., McCammon, J. A., Ellisman, M. H., Gupta, A., Holst, M., McCulloch, A. D., Michailova, A., Papadopoulos, P., Olson, A., Sanner, M., Arzberger P. W. "National Biomedical Computation Resource (NBCR): Developing End-to-End Cyberinfrastructure for Multiscale Modeling in Biomedical Research," CTWatch Quarterly, Volume 2, Number 3, August 2006. http://www.ctwatch.org/quarterly/articles/2006/08/national-biomedical-computation-resource/

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